The probiotic era: unlocking well-aging secrets

New strategies to enhance life quality throughout the aging process

Aging

The elderly population, aged 65 and above, is continuously growing and is expected to double by 2050, reaching 2.1 billion individuals worldwide. Consequently, age-related disorders are receiving more attention since they compromise both life conditions and the autonomy of patients, and lead to an increase in healthcare costs. Indeed, aging is characterized by physiological alterations that impact body composition and functionality, including a reduction in metabolism, cognitive functions, as well as increased frailty, and susceptibility to infections and illnesses. Concurrently, the gut microbiota, recognized as a pivotal “superorgan” of the human body, undergoes significant transformations, particularly in its composition, diversity, and metabolic activity.

 

Gut microbiota changes

One of the major modifications observed in the aging of the gut microbiota is the decline in the abundance of beneficial bacteria, such as Bifidobacteria and Lactobacilli, along with the rise of potentially harmful microbes. This imbalance results in a state of dysbiosis that may be linked to various age-related health conditions. However, unique patterns emerge among centenarians, in which a higher presence of helpful microorganisms, such as Bifidobacterium,

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    AUTHOR

    Marta Lo Re

    SynBalance

    R&D Assistant