Microbiota and brain: friends for sleeping

Could the secret to a peaceful night's rest be found in the health of our gut?

Let’s delve deeper into how the microorganisms inhabiting our bodies play a role in promoting better nighttime rest.

The importance of sleeping. The Sleep Research Society (SRS) recommend sleeping for at least 7 hours per night in the adult population but meeting this recommendation has become increasingly challenging in fast-paced modern world. Reduced sleep time negatively affects both health and social aspects of people’s life, leading to poor work performance, anxiety and depression, as well as increased risk of cardiovascular disease, metabolic disorders, and diabetes. Consequently, individuals actively pursue remedies to enhance their sleep quality, but they often overlooked the crucial contribution of a well-balanced microbiota in achieving this goal.

Physiology of sleeping. Sleep is a physiological state of reduced activity, characterized by changes in brain wave, breathing, heart rate, body temperature, and other functions. It is aligned with the circadian rhythm, which operates on an almost 24-hour cycle synchronized with the alternating light and darkness. The sleep/wake cycle is crucial for tissue restoration and overall body functions. Indeed, sleep comprises two main states: non rapid eye movement (NREM) and rapid eye movement (REM) sleep, each having distinct functions. NREM involves tissue regeneration and immune system strengthening, while REM facilitates dreaming and memory consolidation. The orchestrator of these processes is the dynamic changes of neuropeptides within the central nervous system (CNS). Surprisingly, the main source of these metabolites resides in the gut: the gut microbiota.

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    Born in 2022 as a spin-off of ROELMI HPC, we aim at becoming a leader in biotechnology thanks to all expertise gained in these years, with a huge number of projects fulfilled at worldwide level as well as the network of researchers, contributing to a multi-faced scientific approach.


    Marta Lo Re


    R&D Assistant