With “Gut-Brain-Axis” we refer to a bidirectional cross-talk between intestine and central nervous system. This connection is not only useful to guarantee the correct digestive pathway but thanks to gut microbiota it also possible to positively modulate brain functions. Stress and related sleep disorders are becoming the damage of our time, triggering a vicious circle that could affect our mood sphere. Indeed, this situation led to the development of discomforts like: migraine, fatigue, weakness, lack of energy and vitality, insomnia. If not taken seriously, this condition is accompanied by depressed mood, increased anxiety, and impaired long-term memory for emotional stimuli. Nevertheless, bad sleep can affect hormone levels with negative consequence on weight, blood pressure and immune system.