Genetic and external factors could affect a balanced microbiota moving from a eubiotic to a dysbiotic status (an alteration in microbiota community structure and/or function), capable of causing-driving a detrimental distorted gut homeostasis.
Dysbiosis and dysfunctional gut barrier manifested by epithelial hyper-permeability and high amount of mucosa-associated bacteria are usually observed in Irritable Bowel Syndrome (IBS), Irritable Bowel Disease (IBD), Chron disease or Antibiotic Associated Diahorrea, food intolerance. The findings revealed that the link between aberrant immune responses and dysbiosis might play key roles in fueling disease progression.